Regulatory T cells in the tumor microenvironment suppress the cytotoxic function of effector T cells by secreting interleukin-10 and transforming growth factor-β, thereby mediating immune evasion. Immune checkpoint inhibitors targeting the PD-1/PD-L1 signaling pathway have demonstrated durable objective response rates in various solid tumors, but their efficacy is closely associated with tumor mutational burden and microsatellite instability status.
快速模式Regulatory T cells in the tumor microenvironment suppress the cytotoxic function of effector T cells by secreting interleukin-10 and transforming growth factor-β, thereby mediating immune evasion.
深度模式Within the tumor microenvironment, regulatory T cells suppress effector T cell cytotoxicity through secretion of interleukin-10 and transforming growth factor-β, thereby mediating immune evasion.